SAFE REVERSAL (1): ATROPINE FOLLOWED BY NEOSTIGMINE

Timing of atropine and neostigmine in the reversal of muscle relaxants.

The antimuscarinic effects of atropine were studied in 46 patients to whom neostigmine had been given after operation to reverse the action of a muscle relaxant. Neostigmine was given to alternate patients three minutes after, or together with, atropine, and the effects of the two procedures were compared by measuring the secretions which collected in the buccal and oropharyngeal cavities and o...

Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.

BACKGROUND Sugammadex is a modified [gamma] cyclodextrin compound, which encapsulates rocuronium to provide for a rapid reversal of residual neuromuscular blockade. We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound residual rocuronium-induced blockade than the commonly used cholinesterase inhibitors, edrophonium and neostigmine. METHODS ...

Neostigmine reversal doesn’t improve postoperative respiratory safety

Atropine reversal of hypercarbia during enflurane anaesthesia.

Atropine was given i.v. to 35 spontaneously breathing healthy adults anaesthetized with enflurane to determine if it would reduce PaCO2 by improving gas exchange. Five minutes after administration of atropine, PaCO2 decreased from mean 7.18 to 6.65 kPa (-7%), while mean VE increased from 4.8 to 6.1 litre min-1 (+27%). These changes were maintained 15 min later in the 20 patients studied at that...

Neostigmine versus Sugammadex for Reversal of Neuromuscular Block.

S DEADLINE JULY 1, 2016STEWART L. COHEN, ESQ.A Lawyers Review of Critical SedationRelated Medical Malpractice CasesSTEVEN SHAFER, MDPROFESSOR OF ANESTHESIOLOGYMichael Jackson, Murder, Mayhemand Mystery: The Propofol QuandaryKEYNOTE SPEAKERSJ.R. MARTINEZBEST-SELLING AUTHORSurvival, Strength and Spirit www.PediatricSedationConference.com